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FLASH GENE
Symbol MAGEC2 contributors: mct - updated : 16-10-2019
HGNC name melanoma antigen family C, 2
HGNC id 13574
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 2.95 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2008 41 373 - 2013 23096706
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   moderately
Reproductivemale systemtestis  predominantly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connective    
cell lineage
cell lines testis and liver cancer cell lines, glioma cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved MAGE Homology Domain
  • HOMOLOGY
    interspecies homolog to C.elegans T01D3.6B
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • tumor antigen
  • can promote tumor growth by phosphorylation of TRIM28-Ser824 and by enhancement of DNA damage repair
  • has a role in breast cancer metastasis through inducing epithelial-mesenchymal transition
  • TP53-independent role of MAGEC2 in promoting the survival of myeloma cells
  • is involved in SCF complex and increases the stability of cyclin E in tumor cells
  • is a cancer&
  • 8209;testis antigen, which is highly expressed in various types of tumors, but not in normal tissues with the exception of male germ&
    8209;line cells
  • plays an active role in promoting growth and metastasis of tumor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EID2-MAGEC2 interaction, and N-terminal extension of the EID2 binding domain took part in the EID2-MAGEC2 interaction
  • binds TRIM28, a scaffolding protein that regulates DNA repair
  • MAGEC2 is a new negative regulator of ZMYND11
  • MAGEC2 binds directly to the RING domain protein RBX1, and participates in Skp1-Cullin1-F box protein (SCF) complex
  • MAGEC2 directly interacted with TAF9, which may provide novel information for identifying the oncogenic functions of HCA587/MAGEE1 in tumor cells
  • TRIM28 is necessary for MAGEE1 expression in cancer cells, and TRIM28 is necessary for MAGEE1 expression in cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to chondromalacia
    Variant & Polymorphism SNP
  • rs188900564 in the MAGEC2 associated with chondromalacia
  • Candidate gene
  • MAGEC2/CT-10 may be a good candidate for peptide vaccination in patients with hepatocellular carcinoma
  • Marker
  • expression of MAGEC1/CT7 and MAGEC2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    MAGEC2-specific immunotherapies have the potential to eradicate the most malignant cells within the myeloma tumour bulk leading to durable clinical responses
    cancerreproductivebreast
    targeting MAGEC2 may provide a novel therapeutic strategy for breast cancer treatment
    cancerreproductiveprostate
    potential target for adjuvant and palliative immunotherapy in patients with prostate cancer
    ANIMAL & CELL MODELS