SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| colocalized with TP73 and TP53 in nuclear bodies |
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predominant localization in subnuclear HIPK domains, and small amounts in the cytosol and nucleoplasm |
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colocalizes with ZYX at the cytoskeleton and in the cell nucleus |
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HIPK2 colocalizes with its ubiquitin ligase SIAH1 at nuclear bodies, suggesting that these nuclear domains are the site of HIPK2 ubiquitination |
basic FUNCTION
| playing a role as corepressor for homeodomain transcription factor |
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modulating functions of the TP53 family |
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phosphorylating the antiapoptotic factor CTBP1 and promoting its proteasomal degradation |
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in the Wnt/beta-catenin signaling pathway acting as an intermediate kinase between TAK1 and NLK to promote |
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the proteasomal degradation of c-Myb |
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contributes to drug-induced modulation of MDM2 activity at transcriptional and posttranscriptional levels |
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implicated in regulating various intracellular signalings, such as TGF-beta, BMP, Notch and Wnt signaling |
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tumor suppressor that controls proliferation by antagonizing LEF1/CTNNB1-mediated transcription |
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having an important role as a negative regulator of gene expression, its elimination from promoter-associated repressor complexes allows the induction of a substantial fraction of hypoxia-induced genes |
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implicated in restraining tumor progression by more than one mechanism, involving both its catalytic and transcriptional co-repressor functions |
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phosphorylates ZBTB4 undern ormal condition sof cell growth and down-regulates it |
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phosphorylating MECP2 |
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function as a novel negative regulator of beta-catenin through its phosphorylation and proteasomal degradation |
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negative regulator of Wnt signaling operating via the direct phosphorylation and degradation of beta-catenin, a key component of the Wnt signaling pathway |
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with HIPK1, are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis |
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may function as cell-intrinsic determinants of cell migration in the retina |
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emerging player in cell response to genotoxic agents that senses damage intensity and contributes to the cell choice between cell cycle arrest and apoptosis |
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serine/threonine kinase that acts as a coregulator of an increasing number of factors involved in cell survival and proliferation during development and in response to different types of stress |
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stabilizes CDKN1B by its phosphorylation at serine 10 and contributes to cell motility |
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role of HIPK1, HIPK2 in connecting TGFB1 signaling pathway with the transcriptional programs critical for angiogenesis in early embryonic development |
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plays a key role in radiosensitivity and chemosensitivity |
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conserved function of HIPK2 and PIN1 in the DNA damage-induced apoptosis response |
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is an essential regulator of white fat development |
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HIPK1, HIPK2, HIPK3 share the mechanism of activation by tyrosine autophosphorylation with the closely related DYRK family (dual-specificity tyrosine phosphorylation regulated kinase) |
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is required to complete cytokinesis and impaired HIPK2 expression results in cytokinesis failure and tetraploidization |
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acts as a caretaker gene, whose inactivation increases tumorigenicity and causes chromosomal instability (CIN) by cytokinesis failure |
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highly conserved serine/threonine kinase and is involved in transcriptional regulation |
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importance of HIPK2 in stress mediated cell death, and is a generic stress kinase that gets activated by diverse set of physiological stressors |
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functions as a regulator of developmental processes and as a signal integrator of a wide variety of stress signals, such as DNA damage, hypoxia, and reactive oxygen intermediates |
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role of HIPK2 activation in ER-stress-mediated neurodegeneration |
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regulates malignant growth via phosphorylation of NOTCH1 |