basic FUNCTION
| may play a role in both unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) |
|
ER membrane protein upregulated by ER stress, is implicated in regulation of ERAD |
|
HERPUD1 binding to ubiquilin proteins plays an important role in the ERAD pathway |
|
suggested to improve ER-folding, decrease ER protein load, and participate in ER-associated degradation (ERAD) of proteins |
|
may potentially delay the degradation of cytosolic proteins at the ubiquitination step |
|
ubiquitin domain protein, which is strongly induced by the unfolded protein response |
|
regulates SYVN1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner |
|
likely involved in degradation of immature nicastrin by facilitating VCP-dependent nicastrin retranslocation and ubiquitination |
|
could play a role in the elimination of the excess unassembled components of a multimeric complex |
|
functionally, HERPUD1 plays a role in maintaining ER homeostasis by facilitating proteasome-mediated degradation of ER-resident Ca(2+) release channels |
|
is likely essential for the resolution of ER stress through maintenance of ER Ca(2+) homeostasis |
|
operates as a relevant factor in the defense against glucose starvation by modulating autophagy levels |
|
playslikely a dual role in cellular stress adaptation |
|
endoplasmic reticulum- (ER-) resident membrane protein that plays a role in ER-associated degradation |
|
is involved in endoplasmic reticulum stress response |
|
role of HERPUD1 in the regulation of host innate immunity in response to viral infection |
|
HERPUD1 is a novel negative regulator of pathological cardiac hypertrophy |