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FLASH GENE
Symbol ARTN contributors: - updated : 06-01-2007
HGNC name artemin
HGNC id 727
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two of the four encode the same protein (variant 1 and 2)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1410 22.9 220 - Masure
  • having an alternate 5' UTR
  • encoding the same isoform than variant 2
  • - splicing 1162 22.9 220 - Masure
  • having an alternate 5'UTR
  • encoding the same isoform than variant 1
  • - splicing 1892 24.5 220 - Masure
  • having a different 5' end sequence
  • encoding an isoform with a unique amino terminus
  • - splicing 1160 - 237 - Masure,Rosenblad
    encodes an isoform with a unique amino terminus.
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
     stomach    
    Endocrineparathyroid    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Artn
    intraspecies homolog to artemin
    Homologene
    FAMILY
  • glial cell-lines derived neutrophic factor family of ligand (GDNF)
  • TGF-beta superfamily
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • neutrophic factor involved in stimulation of neurite outgrowth, exerting selective effects on pain sensation
  • ligand for the RET receptor and using GFR-alpha 3 as coreceptor
  • activating the GFR alpha 1 RET receptor complex
  • acting as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues
  • promoting the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after treatment by 6 hydroxydopamine in vivo
  • exhibiting neurotrophic activity on mesencephalic dopaminergic and motor neurons
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • neuroblast proliferation
  • neuronal development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for GFRA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS