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FLASH GENE
Symbol MMP26 contributors: mct/npt - updated : 08-04-2010
HGNC name matrix metalloproteinase 26
HGNC id 14249
DNA
TYPE functioning gene
STRUCTURE 4.23 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
Binding site   transcription factor
text structure
  • a conserved GT-box that binds Sp1/Sp3 proteins and is essential for the basal expression of the gene (Swingler 2010)
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC390038 11 similar to seven transmembrane helix receptor MGC24137 11p15.4 hypothetical protein MGC24137 LOC390039 11 similar to olfactory receptor MOR11-2 OR51E2 11p15 olfactory receptor, family 51, subfamily E, member 2 LOC390040 11 similar to olfactory receptor MOR14-2 LOC390041 11 similar to olfactory receptor MOR14-10 LOC390042 11 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 LOC390043 11 similar to olfactory receptor MOR14-10 LOC390044 11 similar to olfactory receptor MOR14-10 LOC256892 11p15.4 similar to olfactory receptor LOC119696 11p15.4 similar to seven transmembrane helix receptor LOC119695 11p15.4 similar to Olfactory receptor 52R1 LOC119694 11p15.4 similar to Olfactory receptor 51F2 LOC390045 11 similar to olfactory receptor MOR8-3 LOC119692 11p15.4 similar to Olfactory receptor 51S1 LOC119691 11p15.4 similar to Olfactory receptor 51H1 LOC119689 11p15.4 similar to Olfactory receptor 51T1 LOC390046 11 similar to olfactory receptor LOC119687 11p15.4 similar to Olfactory receptor 51A7 OR51A3P 11p15.3 olfactory receptor, family 51, subfamily A, member 3 pseudogene OR51A5P 11p15.3 olfactory receptor, family 51, subfamily A, member 5 pseudogene MMP26 11p15 matrix metalloproteinase 26 LOC119682 11p15.4 similar to Olfactory receptor 51L1 OR51P1P 11p15.3 olfactory receptor, family 51, subfamily P, member 1 pseudogene OR52J2P 11p15.3 olfactory receptor, family 52, subfamily J, member 2 pseudogene LOC119679 11p15.4 similar to Olfactory receptor 52J3 LOC119678 11p15.4 similar to Olfactory receptor 52E2 LOC390049 11 similar to Olfactory receptor 52E1 OR52S1P 11p15.3 olfactory receptor, family 52, subfamily S, member 1 pseudogene OR52E3P 11p15.3 olfactory receptor, family 52, subfamily E, member 3 pseudogene OR52J1P 11p15.3 olfactory receptor, family 52, subfamily J, member 1 pseudogene LOC390053 11 similar to olfactory receptor MOR22-1 LOC390054 11 similar to odorant receptor HOR3beta5 OR52A1 11p15.5 olfactory receptor, family 52, subfamily A, member 1 OR51A1P 11p15.5 olfactory receptor, family 51, subfamily A, member 1 pseudogene LOC283110 11p15.4 similar to odorant receptor HOR3beta2 LOC283111 11p15.4 similar to odorant receptor HOR3beta1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 998 - 261 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  specific
    cell lineage
    cell lines lymphoma cells, tumor cell lines, endometrial tumors
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide, involved in enzyme latency
  • a prodomain
  • a catalytic domain with the zinc binding site and an adjacent threonine residue
  • lacking the hinge region and hemopoxin-like (PEX) C terminal domain
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to macrophage metalloelastase,MMP3,MMP12
    Homologene
    FAMILY
  • stromelysin subclass of MMP family
  • peptidase M10A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • proteolytic enzyme in the extracellular matrix tissue remodeling events associated with tumor progression
  • MMP21, MMP26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • Ca2+
  • protein
  • cleaved gelatin, alpha-protein inhibitors, fibrinogen
  • progelatinase B (activation)
  • binding TIMPs in a 1:1 stoechiometry
  • interacting with STRAP (serine threonine receptor-associated protein (STRAP) is a further protein recruited to the MMP28 promoter and acting functionally with Sp1) (Swingler 2010)
  • HOXA10-mediated expression of MMP26 promotes embryo adhesion during the process of embryonic implantation.
  • cell & other
    REGULATION
    activated by proteinases
    induced by histone deacetylase (HDAC) inhibitors and this effect is mediated through the GT-box (Swingler 2010)
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Merkel cell carcinoma with larger tumors and with poor prognosis(Suomela 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS