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FLASH GENE
Symbol VSIG4 contributors: mct - updated : 21-12-2017
HGNC name V-set and immunoglobulin domain containing 4
HGNC id 17032
DNA
TYPE functioning gene
STRUCTURE 18.39 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Map pter - DXS1213 - VSIG4 - DXS1194 - cen
Authors Langnaese (00)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1535 - 347 - 2006 17016562
7 - 1586 - 305 - 2006 17016562
8 - 1869 - 399 - 2006 17016562
6 - 1927 - 227 - 2006 17016562
7 - 2209 - 321 - 2006 17016562
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine    Homo sapiens
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text several fetal tissues,placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY immunoglobulin superfamily
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases
  • T cells can opposite T cell hyporesponsiveness through dampening VSIG4 inhibitory signals from macrophages and thus maintain their anti-viral function in chronic HBV infection (CHB)
  • B7 family-related macrophage protein that has the capacity to inhibit T-cell activation, and has a potential role in the development of lung cancer
  • acts as a co-inhibitory ligand to negatively regulate T cell proliferation and cytokine production, and its expression is restricted to macrophages
  • functions as a macrophage pattern recognition receptor to directly bind and capture blood-borne Gram-positive bacteria
  • macrophage-associated VSIG4 plays a negative role in helper T cell-dependent isotype switching by inhibiting helper T cell activation and differentiation, and suppressing the isotype switching-inducing cytokine production in antigen-primed CD4(+) helper T cells
  • dual functionality: a negative regulator of T cell activation and a receptor for the complement components C3b and C3c
  • B7 family-related macrophage protein with the capacity to inhibit T-cell activation, having a potential role in cancer
  • inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a strong negative regulator of T cell proliferation and IL2 production
  • VSIG4 signals induce anti-intracellular bacterial phagosome activity in a CLIC3-dependent manner
  • PRKCA promotes the downregulation of VSIG4 and upregulation of ITGAM expression and TNF and IL6 production, a mechanism that may promote inflammation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancers compared with that in benign tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • VSIG4 expression in Multiple myeloma (MM) is an independent indicator of poor prognosis, implying a possible therapeutic target for immunotherapy for MM
  • soluble VSIG4 may be used as a potential biomarker for predicting ovary tumor prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    potential therapeutic target for ovarian cancer
    ANIMAL & CELL MODELS