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FLASH GENE
Symbol CDKL3 contributors: mct/npt - updated : 20-12-2021
HGNC name cyclin-dependent kinase-like 3
HGNC id 15483
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 136.26 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 splicing 2222 - 592 - 2003 12927787
NKIATRE beta or variant 2
9 splicing 1717 57 455 brain, nuclear 2003 12927787
9 - 1355 - 312 - 2003 12927787
10 - 1444 - 312 - 2003 12927787
10 - 1495 - 312 - 2003 12927787
13 - 1982 - 401 - 2003 12927787
11 - 1584 - 418 - 2003 12927787
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
Urinarykidney    
Visualeye    
cell lineage hemopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • MAP kinase dual phosphorylation motif, Thr-Aspi-Tyr motif in kinase subdomain 8
  • a Thr-X-Tyr (TXY) motif in the activation loop domain
  • a nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila RKIALRE
    homolog to C.elegans KKIALRE
    intraspecies homolog to NKIAMRE (CDKL3)
    Homologene
    FAMILY
  • proline-directed kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • restricting cell growth or maintaining differentiation
  • may have a role in regulating cell growth and/or diferentiation
  • may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo stage, supporting the notion that CDKL3 inactivation contributes to non-syndromic mild mental retardation (MR)
  • plays an important role in the regulation of cell growth and/or differentiation
  • is a critical regulator that stimulates Osteosarcoma (OS) progression by enhancing AKT1 activation
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • regulator of cell cycle progression
  • maintenance of normal hematopoiesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDKL3 is a promotor for glioma, probably through the regulation of RRM2 and activation of the JNK signalling pathway
  • cell & other
    REGULATION
    activated by by treatment of cells with phorbol 12-myristate 13-acetate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in mental retardation
    tumoral   deletion    
    in dysmyelopoiesis
    tumoral     --over  
    in esophageal squamous cell carcinoma ESCC) with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for Osteosarcoma (OS) prognosis (
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    potential therapeutic target to treat AKT1 hyper-activated Osteosarcoma (OS)
    cancerdigestiveoesophagus
    may be as a new therapeutic target in ESCC
    cancerbrainglioma/neuroblstoma
    CDKL3 as a promising therapeutic target of glioma
    ANIMAL & CELL MODELS