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FLASH GENE
Symbol ARL6IP1 contributors: mct/npt - updated : 06-01-2016
HGNC name ADP-ribosylation factor-like 6 interacting protein 1
HGNC id 697
DNA
TYPE functioning gene
STRUCTURE 9.87 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2280 23 203 - 2003 12754298
- - 2341 - 174 - 2003 12754298
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunespleen    
Nervousbrain   highly
Respiratorylung    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Lymphoid    
cell lineage myeloid progenitor cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments
  • reticulon-like short hairpin transmembrane domains
  • a COOH-terminal KKXX ER retrieval motif
  • HOMOLOGY
    interspecies ortholog to murine Tbx2
    Homologene
    FAMILY
  • ARL6IP family
  • CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text endoplasmic reticulum (ER) integral membrane protein (Lui 2003)
    basic FUNCTION
  • involved in hematopoietic cell maturation
  • ER integral membrane protein which protects cells by inhibiting caspase-9 activity and having a possible role in cell survival (Lui 2003)
  • addicsin-associated partner that indirectly promotes SLC1A1-mediated glutamate transport activity in a protein kinase C activity-dependent manner
  • addicsin-associated partner that promotes SLC1A1-mediated glutamate transport activity by decreasing the number of addicsin molecules available for interaction with SLC1A1
  • anti-apoptotic protein specific to multicellular organisms, is a potential player in shaping the ER tubules in mammalian cells
  • constricted liposomes into tubules
  • has the ability to shape high-curvature ER tubules in a reticulon-like fashion
  • CELLULAR PROCESS cell life, differentiation
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to ARL6
  • bound directly to addicsin and the hydrophobic region located at amino acids 103-117 of addicsin was crucial to the formation of the ARL6IP1-addicsin heterodimer and addicsin homodimer (Akiduki 2008)
  • binds to atlastin, a GTPase that mediates the formation of the tubular ER network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG61
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS