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FLASH GENE

Symbol

ARHGEF1

contributors: mct - updated : 20-05-2010

HGNC name	Rho guanine nucleotide exchange factor (GEF) 1
HGNC id	681

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	24.34 kb     29 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D19S425 - D19S228 - D19S4121 - D19S223 - ARHGEF1 - D19S217 - D19S2100 - D19S418 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198977 28 - 3137 NP_945328 - 879 - 1996 8810315 NM_004706 29 - 3236 NP_004697 - 912 - 1996 8810315 NM_199002 29 - 3261 NP_945353 - 927 - 1996 8810315

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   tonsils       highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Lsc

Homologene

FAMILY

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	stimulating guanine nucleotide exchange for Rac and Rho
	playing a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors
	regulates the migration and adhesion of marginal-zone B cells, and this regulation appears to be required for these cells to contribute to the antibody response to TD antigens
	role for the exchange factors ARHGEF1 and ARHGEF12 in linking fibronectin signals to downstream RhoA activation
	regulates integrin-mediated adhesive events at the trailing edge of migrating cells
	required by T cells for the development of airway hyperreactivity and inflammation
	with microtubules decide the direction apoptotic cells extrude from an epithelium
	hematopoietic-restricted signaling molecule that regulates leukocyte migration and integrin-mediated adhesion
	regulates alpha5beta1-mediated MMP expression by macrophages and its loss by leukocytes leads to pulmonary pathology
	RhoA guanine exchange factor specifically responsible for AGT–induced activation of RhoA signaling in arterial smooth muscle cells
	mediates the effects of AGT on vascular tone and blood pressure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with GNA13

cell & other

REGULATION

activated by

AGT signaling in vascular smooth muscle cells, and provided evidence that this activation has a causal role in the development of hypertension

Other

phosphorylated by PKCA

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

lungs of Arhgef1-/- mice harbored significantly more leukocytes, increased expression and activity of matrix metalloproteinases (MMPs), airspace enlargement, and decreased lung elastance compared with wild-type lungs