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FLASH GENE
Symbol ARHGEF1 contributors: mct - updated : 20-05-2010
HGNC name Rho guanine nucleotide exchange factor (GEF) 1
HGNC id 681
DNA
TYPE functioning gene
STRUCTURE 24.34 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D19S425 - D19S228 - D19S4121 - D19S223 - ARHGEF1 - D19S217 - D19S2100 - D19S418 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 3137 - 879 - 1996 8810315
29 - 3236 - 912 - 1996 8810315
29 - 3261 - 927 - 1996 8810315
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 tonsils   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Lsc
Homologene
FAMILY
CATEGORY regulatory , signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • stimulating guanine nucleotide exchange for Rac and Rho
  • playing a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors
  • regulates the migration and adhesion of marginal-zone B cells, and this regulation appears to be required for these cells to contribute to the antibody response to TD antigens
  • role for the exchange factors ARHGEF1 and ARHGEF12 in linking fibronectin signals to downstream RhoA activation
  • regulates integrin-mediated adhesive events at the trailing edge of migrating cells
  • required by T cells for the development of airway hyperreactivity and inflammation
  • with microtubules decide the direction apoptotic cells extrude from an epithelium
  • hematopoietic-restricted signaling molecule that regulates leukocyte migration and integrin-mediated adhesion
  • regulates alpha5beta1-mediated MMP expression by macrophages and its loss by leukocytes leads to pulmonary pathology
  • RhoA guanine exchange factor specifically responsible for AGT–induced activation of RhoA signaling in arterial smooth muscle cells
  • mediates the effects of AGT on vascular tone and blood pressure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GNA13
  • cell & other
    REGULATION
    activated by AGT signaling in vascular smooth muscle cells, and provided evidence that this activation has a causal role in the development of hypertension
    Other phosphorylated by PKCA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • lungs of Arhgef1-/- mice harbored significantly more leukocytes, increased expression and activity of matrix metalloproteinases (MMPs), airspace enlargement, and decreased lung elastance compared with wild-type lungs