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FLASH GENE
Symbol EML4 contributors: mct - updated : 06-09-2007
HGNC name echinoderm microtubule associated protein like 4
HGNC id 1316
DNA
TYPE anonymous DNA segment
STRUCTURE 163.00 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Hearing/Equilibriumearinnercochlea highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S, G2
life cycle G0
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal portion (AA 1-249) is essential for the association with microtubules
  • four WD40 repeats
  • a conserved consensus sequence of serine protease
  • a histidine and phosphatase site
  • an EF-hand calcium binding domain
  • N glycosylation and more than phosphorylation sites
  • conjugated PhosphoP
    HOMOLOGY
    intraspecies homolog to EML1
    Homologene
    FAMILY EMAP-like proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION playing a necessary role for correct microtubule formation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hodgkin lymphoma
    tumoral fusion      
    EML4-ALK in non-small-cell lung cancer (NSCLC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS