basic FUNCTION
| receptor for ADP and ATP coupled to G-proteins inhibiting the adenylyl cyclase second messenger system |
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critical for the formation and stabilization of large platelet aggregates |
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P2RX4 as well as P2RY12 is involved in ATP-induced microglial chemotaxis |
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role in the vessel wall response to arterial injury and thrombosis |
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play a crucial role in the stabilization of thrombi formed on atherosclerotic plaques |
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not only is central to ADP-induced platelet activation but also may mediate platelet-independent responses, specifically under conditions of enhanced thrombin formation, such as local vessel injury and atherosclerotic plaque rupture |
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P2RY12 pathway substantially involved in platelet hyperreactivity associated with mild and severe hypercholesterolemia |
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plays a crucial role in hemostasis, undergoing internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function |
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plays a critical role in platelet aggregation, and P2RY12 inhibitors are used clinically to prevent cardiac and cerebral thrombotic events |
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is the primary ADP receptor in osteoclasts |