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FLASH GENE
Symbol SULT1C2 contributors: - updated : 23-07-2007
HGNC name sulfotransferase family, cytosolic, 1C, member 2
HGNC id 11456
DNA
TYPE functioning gene
STRUCTURE 21.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2799 34 296 - Freimuth
- - 2832 - 307 - Freimuth
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 salivary gland   highly
Endocrineparathyroid   highly
Nervousspinal cord   lowly
Reproductivefemale systemovary  lowly
 male systemprostate   
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in lung and kidney and lowly in heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
sulfotransferase domain
HOMOLOGY
interspecies homolog to Drosophila CG5428
homolog to C.elegans T15D6.1
Homologene
FAMILY sulfotransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • transfer the sulpho moiety from the cofactor 5'-phosphoadenosine-3'-phosphosulphate (PAPS) to nucleophilic groups of xenobiotics and small endogenous compounds (such as hormones and neurotransmitters)
  • involved in the activation of carcinogenic hydroxylamines
  • catalyzing the sulfate conjugation of many drugs, xenobiotic compounds, hormones and neurotransmitters
  • involved in biotransformation of endogenous and exogenous substrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS