Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TOMM20 contributors: mct - updated : 05-02-2018
HGNC name translocase of outer mitochondrial membrane 20 homolog (yeast)
HGNC id 20947
DNA
TYPE functioning gene
STRUCTURE 19.60 kb     5 Exon(s)
regulatory sequence Binding site   transcription factor
text structure
  • a NRF-2 binding motifs in the 5'-flanking region
  • two NRF-1 binding motifs in the 5'-flanking region (distal NRF-1 binding site is not functional)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3407 - 145 - 1998 9748310
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineparathyroid   moderately
    Hearing/EquilibriumearinnercochleaCortimoderately Homo sapiens
    Nervousbrain   moderately
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell Homo sapiens
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transmembrane segment containing critical AAs essential for docking the TOMM20 receptor into its correct environment within the TOM complex
  • N-terminal TOMM20-binding element essential for targeting to mitochondria
  • C-terminal element increasing efficiency of protein import in the step prior to translocation across the inner membrane
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Mas20p
    ortholog to rattus Tomm20 (97.9pc)
    ortholog to murine Tomm20 (99.3pc)
    ortholog to Drosophila Tom20 (59.4pc)
    Homologene
    FAMILY
  • TOM20 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • mitochondrial outer membrane translocase complex
  • distributions of clusters of TOMM20 and of TOMM22 follow an inner-cellular gradient from the perinuclear to the peripheral mitochondria
  • basic FUNCTION
  • import receptor involved in the recognition and translocation of cytosolically synthesized mitochondrial preproteins
  • functioning with TOMM22 as the transit peptide receptor at the surface of the mitochondrion outer membrane
  • facilitating the movement of preproteins into the TOMM40 translocation pore
  • major import receptor that recognizes preferentially mitochondrial presequences
  • apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import as TOMM22
  • master receptor for protein import into mitochondria
  • recognizes the targeting sequence on incoming mitochondrial precursor proteins, binds these protein ligands, and then transfers them to the core complex for translocation across the outer membrane
  • mediates localization of mRNAs to mitochondria in a translation-dependent manner
  • plays an essential role in specificity of mitochondrial protein import
  • has a dual role in protein import into mitochondria: recognition of the targeting signal in the presequence and tethering the presequence to the TOMM40 complex to increase import efficiency
  • functions as a receptor for the N-terminal presequence of mitochondrial-precursor proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mitochondrial import complex
  • central component of a mitochondrial receptor complex
  • mitochondrial outer membrane translocase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TOMM22 and leader sequence of nuclear coded matrix space precursor proteins
  • competes with the chaperones for TOMM70A binding
  • AIP-TOMM20 recognition contributes to cell survival in development and cancer by mediating the mitochondrial import of BIRC5
  • FBXO7 ubiquitinated TOMM20, and its levels correlated with FBXO7 expression, indicating a stabilizing effect
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neoplastic lymphocytes 2)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • TOMM20 can be used in the inner ear as a marker for mitochondrial protein import
  • Therapy target
    ANIMAL & CELL MODELS