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FLASH GENE
Symbol FLOT1 contributors: mct/shn - updated : 10-05-2013
HGNC name flotillin 1
HGNC id 3757
DNA
TYPE functioning gene
STRUCTURE 14.94 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D6S1022 - D6S1624 -FLOT1 - D6S1615 - D6S1014 - cen
RNA
TRANSCRIPTS type messenger
text alternative polyadenylation signals
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1839 47.2 427 - 2001 11167132
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • hydrophobic N terminal region
  • SPFH domain
  • long central alpha helical domain forming a coiled-coil
  • mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to Flot 1, Mus musculus
    ortholog to Flot 1, Rattus norvegicus
    ortholog to flot1, Danio rerio
    ortholog to FLOT1, Pan troglodytes
    intraspecies homolog to prohibitin
    Homologene
    FAMILY
  • EPB72/stomatin family
  • band 7/mec-2 family
  • flotillin subfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • membrane associated protein of caveolae
  • cholesterol enriched microdomains (lipid rafts)
  • localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1
  • basic FUNCTION
  • formation of filopodia
  • playing a role in formation of caveolae or caveolae-like vesicles and in cholesterol enriched microdomains (lipid rafts) formation
  • defining structural components of the machinery that mediates a clathrin-independent endocytic pathway
  • STX12, FLOT1, and ABCA1 were identified as phagosomal proteins, indicating the involvement of the phagosomal compartment in ABCA1-mediated lipid efflux
  • defining structural components of the machinery that mediates a clathrin-independent endocytic pathway
  • regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells
  • participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility
  • with FLOT2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins, regulated by FYN kinase
  • FLOT1 signaling pathway for hippocampal neurite branching is regulated by LRFN3
  • a critical role of Flot1-enriched membrane microdomains in protein kinase C-triggered DAT endocytosis and the actions of amphetamine (
  • plays a direct role during both the early phase and late phase of growth factor signaling
  • a scaffolding factor in the regulation of classical MAP kinase signaling
  • FLOT1, FLOT2-dependent endocytosis is unlikely to be a major pathway in the syncytiotrophoblast (ST), but may be important in the cytotrophoblasts (CTs) and endothelium
  • functional role for flotillins, especially FLOT2, in cell-cell adhesion in non-malignant epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of rafts/microdomains
  • forming a ternary complex with CBL and the adaptor protein CAP that could be crucial in the regulation of glucose uptake
  • organized as homo- and hetero-tetramers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTOV1
  • adapter protein CAP and Cbl proto-oncogene (
  • Neuroglobin, Ngb (
  • Arginase (
  • caveolin 1, CAV1 and caveolin 2, CAV2
  • amyloid precursor protein, APP (
  • is a molecular mediator of neurite branching for LRFN3
  • functional role of FLOT1, FLOT2 in NPC1L1-mediated cholesterol uptake, elucidating the formation of NPC1L1-FLOT1, FLOT2-positive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption
  • EGFR, CRAF, MEK1, ERK, and KSR1
  • by promoting EGFR internalization, FLOT1, FLOT2 restrict the EGFR signaling involved in CDH1 macropinocytosis and recycling and regulate adherens junctions (AJs) formation and dynamics and thereby cell adhesion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knockdown of flotillin-1/reggie-2 results in reduced EGF-induced phosphorylation of specific tyrosines in the EGF receptor and in inefficient activation of the downstream mitogen-activated protein kinase and Akt signaling