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FLASH GENE
Symbol SLC2A6 contributors: KTN/npt - updated : 07/11/2008
HGNC name solute carrier family 2 (facilitated glucose transporter), member 6
HGNC id 11011
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • several lymphocyte-specific transcription factor-binding motifs
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2487 54.4 507 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveesophagus   moderately
     pancreas exocrine   moderately
    Endocrineplacenta   moderately
    Lymphoid/Immunespleen   predominantly
     tonsils   highly
    Nervousbrain   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loops, respectively between TM2 and 3 and TM8 and 9, both with the conserved RXGRR motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog SLC2A6 (87.9 pc)
    homolog to chimpanzee SLC2A6 (99.6 pc)
    homolog to cow SLC2A6 (87.2 pc)
    homolog to rattus Slc2a6 (83.4 pc)
    homolog to murine Slc2a6 (83.4 pc)
    Homologene
    FAMILY
  • solute carrier family 2
  • major facilitator superfamily
  • sugar transporter (TC 2.A.1.1) family
  • glucose transporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a facilitated glucose transporter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text sugar transport (sugar:hydrogen symporter)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS