Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FGD3 contributors: mct/npt - updated : 16-02-2009
HGNC name FYVE, RhoGEF and PH domain containing 3
HGNC id 16027
DNA
TYPE functioning gene
STRUCTURE 88.92 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
text variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3470 79.3 725 - Humphray (2004)
18 - 3370 79.3 725 - Humphray (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Reproductivemale systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Rho GEF (DBL) domain
  • multiple phosphoinositide-binding domains
  • a pleckstrin homology domain (PH)
  • a distinctive FYVE domain
  • a second C terminal PH domain
  • HOMOLOGY
    interspecies ortholog to murine Fgd3
    Homologene
    FAMILY
  • FGD1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • modulate the actin cytoskeleton, being Cdc42-specific exchange factors (Huber 2008)
  • likely couple the actin cytoskeleton with the plasma membrane (Nakanishi 2008)
  • with FGD1 play different roles to regulate cellular functions but their intracellular levels are tightly controlled by the same destruction pathway through SCF(FWD1/beta-TrCP) (Hayakawa 2008)
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS