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FLASH GENE
Symbol OGN contributors: mct - updated : 27-01-2014
HGNC name osteoglycin (osteoinductive factor, mimecan)
HGNC id 8126
DNA
TYPE functioning gene
STRUCTURE 20.73 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   enhancer   silencer   metal/iron
text structure
  • enhancer and silencer element in the first intron (TP53 binding site and interferon stimulated response element, ISRE )
  • three initiator element, an E-box,and Oct-1, metal response element
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2786 - 298 - Madisen, Mehrle
    - splicing 2793 - 316 - Madisen, Mehrle
    7 - 3068 - 298 - Madisen, Mehrle
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselaorta  highly Mus musculus
    Endocrineneuroendocrinepituitary    Homo sapiens
     parathyroid    
    Hearing/Equilibriumearinnercochlea highly Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell Mus musculus
    not specificchondrocyte Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    four leucine-rich repeats flanked by cysteine-rich regions
    HOMOLOGY
    interspecies homolog to murine Ogn
    Homologene
    FAMILY small leucine-rich proteoglycan family,class III
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    text extracellular matrix
    basic FUNCTION
  • inducing bone formation in conjunction with transforming growth factor beta (TGFB1, TGFB2)
  • pituitary secretory protein, playing an important role in the regulation of cellular growth
  • may be modifiing the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis
  • its downregulation is a fundamental requirement for proper arteriogenesis
  • important regulator of left ventricular mass through modulation of the TGF-beta pathway
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • may be a crucial humoral bone anabolic factor that is produced by muscle tissues
  • may be an important factor produced by muscle-derived cells and secreted into blood that exhibits bone anabolic effects
  • might play an important role in bone formation by osteoblasts at the well differentiated stage
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS development
    text bone formation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OGN expressed in pituitary corticotroph cells mainly regulates ACTH secretion in the pituitary and coordinates the hypothalamo-pituitary-adrenal axis (HPAA)
  • cell & other
    REGULATION
    Other regulated by pituitary transcription factor-1 (POU1F1) as a marker for diagnosing pituitary tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    its overexpression antagonized BMP2-induced differentiation of myoblastic cells into osteoblasts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ogn-deficient mice, have normal hearing thresholds