protein
| NKKB2 (p49) in the IKK complex |
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MMS22L and TONSL interact with each other and with FACT (facilitator of chromatin transcription) and MCM (minichromosome maintenance) complexes |
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physically and functionally interacts with MMS22L that co-purifies with histones, several chromatin remodelling and DNA replication/repair factors |
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in conjunction with its obligate binding partner, MMS22L, is necessary for the repair of replication-associated DNA damage |
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by specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their HR-mediated restart |
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replication-dependent histone chaperones are required for the recruitment of MMS22L-TONSL during homologous recombination (HR) to load RAD51 onto ssDNA |