protein
| ubiquitin C-terminal hydrolase, UCH-L3 |
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culin 1, CUL1 |
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NEDD8 Ultimate Buster-1, NUB1 |
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ROC1-CUL1 |
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aryl hydrocarbon receptor, AhR |
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negative regulator of ubiquitin-like proteins 1 like, NUB1L |
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ubiquitin-like protein FAT10 |
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Ulp/Senp protease family member Den1 |
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breast cancer-associated protein 3, BCA3 |
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Cullin3, Cul3 |
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crucial regulator of RPL11 signalling to TP53 |
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NEDD8 is an ancillary player to regulate the stability of HIF1A |
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PRKN and PINK1 are NEDD8 conjugated |
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UBXD7, associate only with the active, NEDD8- or Rub1-modified form of cullins |
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E2F1 is a substrate for NEDD8 post-translational modification (NEDDylation results in decreased E2F1 stability, lower transcriptional activity and slower cell growth) |
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NEDD8 is conjugated to RCAN1 (RCAN1-1S) via three lysine residues, K96, K104, and K107 (neddylation enhances RCAN1 protein stability without affecting its cellular location) |
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plays an important role in the ubiquitination of SCNN1A in alveolar epithelial cells |
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NUB1L directly interacted with NEDD8, but not with ubiquitin, on the key residue Asn-51 of NEDD8 and with VCP on its positively charged VCP binding motif |
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COPS5 acts potentially as a positive regulator of IFN responses by stabilizing IFNR through antagonizing the NEDD8 pathway |
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physically SMURF1 interacts with NEDD8 and UBE2M, forms a NEDD8-thioester intermediate, and then catalyses its own neddylation on multiple lysine residues |
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MDM2 binds to and is involved in conjugating either ubiquitin or NEDD8 to TP53 |
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NEDD8 targets ubiquitin ligase SMURF2 for neddylation and promote its degradation |
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KHNYN has a stark preference for NEDD8 |
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NEDD8 acts as a nexus that binds disparate cullin elements and the RING-activated ubiquitin-linked UBE2D1 |
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HSPA4 chaperone is sensor of the NEDD8 cycle upon DNA damage |
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with ubiquitin function as covalent modifiers of other proteins but are also themselves subject to post-translational modifications including phosphorylation |
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ERBB2 directly interacts with NEDD8 and NAE1, whereas ERBB2 protein expression is decreased by neddylation depletion |
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