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FLASH GENE
Symbol HS6ST1 contributors: mct - updated : 11-04-2015
HGNC name heparan sulfate 6-O-sulfotransferase 1
HGNC id 5201
DNA
TYPE functioning gene
STRUCTURE 53.12 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3966 48.1 411 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal transmembrane domain
  • two potential N glycosylation sites and cleavage site near the C terminus
  • HOMOLOGY
    interspecies ortholog to murine Hs6st1
    Homologene
    FAMILY
  • sulfotransferase 6 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II integral membrane protein
    basic FUNCTION
  • transfering a sulfate from 3-prime_phosphoadenosine 5-prime phosphosulfate to position 6 of the N-sulfoglucosamine residue of heparan sulfate
  • extracellular matrix maintenance
  • HS2ST1 and HS6ST1 are each deployed to generate distinct patterns of heparan sulfation on retinal ganglion cell and at the optic chiasm
  • important gene that contributes pathogenic alleles to the genetic network responsible for the neuroendocrine control of human reproduction
  • HS6ST1 and HS6ST2 are essential for cranial axon patterning
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS excretion
    PATHWAY
    metabolism other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHI3
    Susceptibility
    Variant & Polymorphism
    Candidate gene premature ovarian failure (POF1)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Hs6st1-null mice failed to thrive and exhibited growth retardation, body weight loss, enlargement of airspaces in the lung and, in some cases, lethality