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FLASH GENE
Symbol SF3A1 contributors: npt/ - updated : 12-02-2007
HGNC name splicing factor 3a, subunit 1, 120kDa
HGNC id 10765
DNA
TYPE functioning gene
STRUCTURE 24.94 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - ADORA2A - TIMP3 - [D22S1144 - SLC5A1 - NF2 NF2 - TCN2 TCN2 - D22S280 ] - qter
Authors Gene Map (98),LDB (99)
Text [SF3A1 ]
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4941 81.5 728 - -
- - 5136 88.7 793 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SURP module identified in the essential splicing factor PRP21 of S cerevisiae and binding to SF3A3
  • a C terminal domain binding to SF3A2
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae PRP21
    ortholog to Drosophila alternative regulator suppressor-of-white-apricot
    homolog to C.elegans four proteins
    homolog to mammals
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • converting U2 SnRNP in its active form
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome
  • component of "a" complex of three subunits SFRA1, SFRA2, SFRA3, anchoring to the branch point in pre-mRNA seqence
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SnRNP-associated splicing activities, activating U2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS