Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LGALS4 contributors: mct - updated : 02-04-2020
HGNC name lectin, galactoside-binding, soluble, 4
HGNC id 6565
DNA
TYPE functioning gene
STRUCTURE 11.94 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1121 35.9 323 - 2017 28947766
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus     Homo sapiens
 intestinelarge intestinecolon   Homo sapiens
 intestinesmall intestine    Homo sapiens
 mouthtongue    Homo sapiens
 stomach     Homo sapiens
Nervousbrainlimbic systemhippocampus   Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal carbohydrate-recognition domain
  • two carbohydate binding domains
  • C-terminal carbohydrate recognition domain, involved in recognition of glycosphingolipids, sulfated saccharides and blood group antigens
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the assembly of adherens junction
  • plays a unique role in the intestine and assign a novel role of this protein in controlling intestinal inflammation by a selective induction of T cell apoptosis and cell cycle restriction
  • tandem-repeat-type galectin that is expressed in the epithelium of the alimentary tract from the tongue to the large intestine
  • involved in epithelial glycoprotein transport
  • is required for axon growth and for the organization of axonal membrane L1 delivery and clustering
  • plays an important role in metastatic process of lung adenocarcinoma
  • role of LGALS4 and other galectins in basolateral to apical epithelial transcytosis
  • may function as a tumor suppressor gene in urothelial carcinoma (UC) progression, and methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression
  • neurons establish axon membrane domains expressing LGALS4, the first inhibitor of myelination identified in axons, whose regulated boundaries delineate myelination-incompetent axon segments along development
  • may likely exert the immunoregulatory functions through the activation and differentiation of monocytes
  • played a critical role in the progression of urothelial carcinoma of the bladder
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LGALS4 interacts with the drug transporter SLC28A3 to regulate its function
  • could bind to CD14 on monocytes and induce their differentiation into macrophage-like cells through the MAPK signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal and hepatocellular carcinomas
    tumoral       gain of function
    in Bladder cancer patients when compared with normal subjects
    tumoral     --low  
    is a predictor of worse prognosis in pancreatic cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for a soluble regulator of oligodendrocytes (OLGs) differentiation and, hence, myelination (
  • Marker
  • potential biomarker for diagnosis and treatment of urothelial carcinoma of the bladder
  • LGALS3, LGALS4 may be potential noninvasive markers for the identification of Parkinson disease and advanced stages
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    is a novel anti-inflammatory agent that could be therapeutically effective in diseases with a disturbed T cell expansion and apoptosis such as inflammatory bowel disease
    ANIMAL & CELL MODELS