protein
| nicastrin |
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phospholipid scramblase 1, PLSCR1 |
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Presenilin-1, PS1 |
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P-selectin glycoprotein ligand 1, PSGL-1 |
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golgi-associated, gamma adaptin ear containing, ARF binding protein 1, GGA1 |
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brain-specific type II membrane protein BRI3 |
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lipoprotein receptor-related protein, LRP |
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in addition to its role in APP trafficking--LRP1 affects APP processing by competing for cleavage by BACE1 |
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SCF(Fbx2) -E3 ligase |
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SORT1 |
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NRG1 |
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SREBF2, which can be modulated by the impairment of cerebral cholesterol homeostasis, has a direct role on BACE1 expression and may be involved in Alzheimer disease progression |
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is capable of cleaving APP in late compartments of the secretory pathway |
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L1CAM and CHL1 are physiological substrates for BACE1 |
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APP-activated NFATC3 proteins were associated with astrocytic BACE1 gene expression via direct interaction with the BACE1 promoter region |
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APP-induced elevation of intracellular calcium levels potentiates BACE1 gene expression via calcineurin-related signaling in astrocytes |
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DNM1 likely affects amyloid generation through regulation of BACE1 subcellular localization and therefore its enzymatic activities |
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KCNE1 and KCNE2 cleavages are regulated by BACE1 and PSEN1/gamma-secretase activities under physiological conditions |
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RHEB interacts with BACE1 and degrades it through proteasomal and lysosomal pathways |
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BACE1-mediated CNTN2 cleavage tightly regulates the surface expression of CNTN2 in neuronal cells |
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BACE1 can effectively shed the membrane-anchored signaling molecule JAG1 but BACE1 fails to cleave JAG2 |
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RTN3 has previously been shown to interact with BACE1 and negatively regulate BACE1 activity |
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direct binding of NFATC4 to specific DNA sequences within BACE1 promoter region |
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novel role of CLEC4G in negatively regulating BACE1 function |
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link between TPPP and BACE1 in AD brains, suggesting that upregulated CDK5 activation by TPPP accelerates AD pathogenesis by enhancing BACE1 activity via phosphorylation |
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BACE1 modulates gating of KCNQ1 and cardiac delayed rectifier KCNQ1/KCNE1 (IKs) |
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SEPTIN8 modulates likely bta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1 |
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USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501 |
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EGR1 promotes APP synthesis via transcriptional activation of BACE1, suggesting that EGR1 plays role in activation of BACE1 and acceleration of APP synthesis in Alzheimer disease brain |
| BACE knockout mice develop normally and showed no consistent phenotypic differences from their wild-type littermates, including overall normal tissue morphology and brain histochemistry, normal blood and urine chemistries, normal blood-cell composition, and no overt behavioral and neuromuscular effects | |
Brain and primary cortical cultures from BACE knockout mice showed no detectable beta-secretase activity, and primary cortical cultures from BACE knockout mice produced much less Abeta from APP |
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BACE1 null mice engineered to overexpress human APP (BACE1(-/-).Tg2576(+)) are rescued from Abeta-dependent hippocampal memory deficits |
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amyloid precursor protein processing was altered in the BACE knockouts with Abeta levels decreasing and the levels of APLP2 proteolytic products were decreased |
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Overexpression of BACE in cultured cells led to increased APLP2 processing |
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a significant number of BACE1 knockout mice died in the first weeks after birth but the surviving are smaller than their littermate controls and present a hyperactive behavior and a subtle alterations in the steady-state inactivation of voltage-gated sodium channels was observed |
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enhanced memory and synaptic plasticity of mice overproducing APP are abolished by the ablation of one or both copies of the BACE1 gene, leading to a significant decrease in AICD but not of any other APP cleavage products |
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Cdk5 level and p25:p35 ratio were elevated and correlated with BACE1 level in brains of AD patients and 5XFAD transgenic mice |