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FLASH GENE

Symbol

ATF7

contributors: mct - updated : 31-05-2016

HGNC name	activating transcription factor 7
HGNC id	792

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	118.56 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001130060 12 - 6641 NP_001123532 - 462 - 2011 21858082 NM_006856 12 - 6704 NP_006847 - 483 - 2011 21858082 NM_001206682 - - 867 NP_001193611 - 117 - 2011 21858082 ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors NM_001206683 - - 776 NP_001193612 - 117 - 2011 21858082

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly   salivary gland       highly Lymphoid/Immune lymph node       moderately Reproductive female system uterus cervix       male system prostate       Urinary bladder       highly   kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective       moderately Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	a consensus sumoylation motif (IKEE), located within the N-terminal activation domain
	a C2H2-type zinc finger domain
	a conserved basic leucine zipper (bZIP) domain

conjugated

PhosphoP , sumoylated , Other

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to rattus Atf7 (96.4 pc)
	homolog to murine Atf7 (97.3 pc)

intraspecies	homolog to ATF4
	homolog to ATF2

Homologene

FAMILY	BZIP family
	cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome,euchromosome

basic FUNCTION	transcriptional activation
	may have a critical role in gene expression induced by social isolation stress
	ATF7 and DMRT2 play key roles in paternal stress-induced telomere shortening in the offspring

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimerizing with other ATF
	heterodimerize with JUN or FOS proteins and its transcriptional activity is mediated by interaction with TAF12, a subunit of the general transcription factor TFIID

INTERACTION

DNA	binding to cAMP responsive element

RNA

small molecule	metal binding,
	Zn2+

protein	with PRL1 protein tyrosine phosphatase
	binds to CRE elements within specific promoters
	TAF12, a component of the TFIID general transcription factor, mediates ATF7 transcriptional activity through direct interactions between the two proteins
	ATF7 silences the transcription of HTR5B by directly binding to its 5prime-regulatory region, and mediates histone H3-K9 trimethylation via interaction with the ESET histone methyltransferase
	ATF7 interacts with TAF12 and contributes to the hypersensitivity of Osteoclast (OCL) precursors to 1,25-(OH)&
	8322;D&
	8323; in in Paget disease

cell & other

REGULATION

activated by

stress and growth factors that activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain

induced by

the adenovirus E1a13S mRNA product

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei