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FLASH GENE
Symbol TDRKH contributors: mct - updated : 25-03-2014
HGNC name tudor and KH domain containing
HGNC id 11713
DNA
TYPE functioning gene
STRUCTURE 20.27 kb     17 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha PSMD4 1q21.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 KIAA1441 1q21.3 KIAA1441 protein PIK4CB 1q21 phosphatidylinositol 4-kinase, catalytic, beta polypeptide RFX5 1q21 regulatory factor X, 5 (influences HLA class II expression) SELENBP1 1q21-q22 selenium binding protein 1 PSMB4 1q21 proteasome (prosome, macropain) subunit, beta type, 4 POGZ 1q21.1 pogo transposable element with ZNF domain CGN 1q21 cingulin TUFT1 1q21-q23 tuftelin 1 SNX27 1q21.3 sorting nexin family member 27 TNRC4 1q21 trinucleotide repeat containing 4 FLJ36032 1q21.3 hypothetical protein FLJ36032 MRPL9 1q21 mitochondrial ribosomal protein L9 OAZ3 1q21.3 ornithine decarboxylase antizyme 3 TDRKH 1q21 tudor and KH domain containing protein LOC339398 1q21.3 similar to DAAT9248 LOC388696 1 LOC388696 RORC 1q21 RAR-related orphan receptor C FLJ37964 1q21.3 hypothetical protein FLJ37964 CTMP 1q21 C-terminal modulator protein LOC391099 1 similar to keratin 8, type II cytoskeletal - human S100A10 1q21 S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) LOC391100 1 similar to KIAA1245 protein S100A11 1q21.2-q22 S100 calcium binding protein A11 (calgizzarin) LOC126637 1q21.3 similar to RIKEN cDNA 5430400H23 THH 1q21 trichohyalin FAM16B 1q21 family with sequence similarity 16, member B FLJ39117 1q21.3 hypothetical protein FLJ39117 LOC388697 1 hypothetical gene supported by AB104446
regionally located mapped to the epidermal differentiation complex (FDC)
RNA
TRANSCRIPTS type messenger
text multiple, by alterbnative splicing and poliadenylation ; Variants 1, 2, and 3 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2854 62 561 - 2000 10767542
13 - 2829 62 561 - 2000 10767542
14 - 2343 62 561 - 2000 10767542
13 - 2719 57.1 516 - 2000 10767542
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TUDOR and KH domains
  • HOMOLOGY
    intraspecies homolog to Iclu (nucleotide-sensitive conductance regulator)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • playing a role in epithelial function
  • required for spermatogenesis and involved in piRNA biogenesis
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation by epidermis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TDRKH partners with PIWIL1 and PIWIL4 via symmetrically dimethylated arginine residues in PIWIL1 and PIWIL4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Tdrkh mutants display meiotic arrest at the zygotene stage, attenuate methylation of Line1 DNA, and upregulate Line1 RNA and protein, without inducing apoptosis