SUBCELLULAR LOCALIZATION
| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,cytosolic,granule
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text
| target membrane t-SNARE |
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synapse |
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SNAP23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane ( |
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was localized to the plasma membrane |
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enriched in dendritic spines |
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membrane association of all SNAP25/23 proteins is enhanced by Golgi-localized DHHC3, DHHC7, and DHHC17 |
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in neutrophils, SNAP23 is mainly distributed on cytoplasmic granules (specific and gelatinase-rich tertiary granules) and mediates the secretion of these granules |
basic FUNCTION
| regulating the transport vesicle docking and fusion |
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annexin A2 and SNAP23 are involved in the same pathway in the regulation of lung surfactant secretion |
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having essential functions in presynaptic neurotransmitter release |
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functions in regulated exocytosis pathways in cell types such as mast cells, adipocytes and possibly in constitutive exocytosis pathways throughout the body |
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play essential roles as SNARE proteins in membrane fusion events that occur at the plasma membrane |
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critical for regulated exocytosis in non-neuronal cells |
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important for the functional regulation of postsynaptic glutamate receptors |
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implicated in phagocytosis by macrophages |
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potential involvement of SNAP23 in both phagosome formation and maturation in macrophages, presumably by mediating SNARE-based membrane traffic |
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regulates phagosome formation and maturation by mediating membrane fusion in macrophages |
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phagosomal SNAP23 is likely one of the key players regulating the phagosomal environment in macrophages |
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is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis |
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is involved in microvesicle trafficking and exocytosis in various cell types |
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is essential for secretory granule fusion in several cell lines |
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opposing roles for SNAP23 in secretion in pancreatic exocrine and endocrine cells |
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may serve as an oncogene promoting tumorigenicity of ovarian cancer cells by decreasing apoptotic process |
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Syntaxin-4 and SNAP23 acted as exocytic SNAREs to release NGF from Schwann cells (SCs) |
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role for SNAP23 in the control of macroautophagy and programmed cell death |