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FLASH GENE
Symbol IL36RN contributors: mct - updated : 26 -08 -20
HGNC name interleukin 36 receptor antagonist
HGNC id 15561
Corresponding disease
GPP generalized pustular psoriasis
Location 2q13      Physical location : -
Synonym name
  • IL9 related protein 3,interleukin 1 delta
  • interleukin 1 receptor antagonist homolog 1
  • interleukin-1 HY1
  • interleukin 1 family, member 5 (delta)
  • IL-1-related protein 3
  • Synonym symbol(s) FIL1D, IL1HY1, IL1L1, IL1RP3, MGC29840, UNQ1896/PRO4342, FIL1, FIL1(DELTA), IL1F5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 6.00 kb     5 Exon(s)
    text structure two alternative non coding first exons
    MAPPING cloned Y linked N status confirmed
    Map cen - IL1A - IL1B - IL1F7 - IL1F9 - IL1RN - IL1F5 - qter
    Authors Busfield (00)
    regionally located cluster of IL1related genes
    RNA
    TRANSCRIPTS type messenger
    text two alternative non coding first exons
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 initiation site 2717 17 155 - 2000 10744718
    5 - 2689 - 155 - 2000 10744718
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus     Homo sapiens
    Respiratoryrespiratory tracttrachea    Homo sapiens
    Skin/Tegumentskin   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Lymphoid    
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Digestiveepithelial cell Homo sapiens
    Lymphoid/Immunemacrophage
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve stranded beta-trefoil structure
  • has the same beta-trefoil fold as other IL1 family members, and the hydrophobic core is well conserved, but there are substantial differences in the loop conformations
  • conjugated GlycoP , Other
    HOMOLOGY
    interspecies ortholog to murine Il1f5
    Homologene
    FAMILY interleukin 1 cytokine family
    CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • putative antagonist of IL1 receptor
  • involved in innate immune responses to infection and injury
  • mediates anti-inflammatory effects through its ability to induce IL4 production and this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8
  • primary inflammatory cytokine, that may play an important role in the susceptibility to developing rheumatoid arthritis
  • IL1 family receptor antagonist, which opposes the activity of the IL36A and IL36G innate cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating NF-kappa B through the IL1 receptor
  • bind to specific receptors and cause activation of NFkappaB and MAP kinase
  • cell & other
    REGULATION
    induced by phorbol ester (PHA) and lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    corresponding disease(s) GPP
    Susceptibility
  • .to common forms of psoriasis
  • Variant & Polymorphism other putative dysregulation of the interleukin-36–interleukin-36Ra signaling pathway may confer a predisposition to common forms of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS