Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL36G contributors: mct - updated : 24-11-2017
HGNC name interleukin 36 gamma
HGNC id 15741
Location 2q13      Physical location : -
Synonym name
  • IL1 related protein 2
  • interleukin 1 homolog 1
  • interleukin 1 family, member 9
  • Synonym symbol(s) IL1-F9, IL1RP2, , IL1H1, IL1H2, IL1-H2IL1H1, IL1F, IL1F9
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 7.65 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1212 - 169 - 2016 27183581
    4 - 1107 - 134 - 2016 27183581
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestiveesophagus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY interleukin 1 cytokine family
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • initiation and promotion of the host response to injury or infecion by activating a set of factors including NFKB, AP1 which, in turn, induce production of effectors of the immune response mediated by IL1 receptor beta
  • IL36G, besides IFNG may contribute to functions of TBX21 transcription factor in immunopathology
  • counting on CAMP induction in innate stimuli, such as in infection and wounding, IL36G induction by cathelicidin would explain the mechanism of initiation of skin inflammation and occasional exacerbations of psoriasis and skin diseases by general infection
  • role of IL36G in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy
  • induction and regulation of the proinflammatory cytokine IL36G during tuberculosis
  • is involved in host defense and contributes to proinflammatory responses and development of inflammatory disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • inhibited by IL1 family members IL1F5, IL-1delta, interferon gamma
  • stimulated fy TNFA, IL1-beta in keratinocytes
  • protein
  • stimulated the expression of the neutrophil chemokines IL8 and CXCL3 and the Th17 chemokine CCL20 in lung fibroblasts
  • IL36A, IL36B, IL36G cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells
  • IL36G expression was induced by the combination of IL1B and TNF via activation of MAPKs and transcription factors, NFKB1 and JUN in colonic myofibroblasts
  • directly IL36G stimulates proliferation of keratinocytes, and it induces expression of keratinocyte mitogens in fibroblasts, suggesting that the NFE2L2-IL36G axis promotes keratinocyte proliferation through a double paracrine loop
  • cell & other
  • also induced by a contact hyperimmunity reaction or herpes simplex virus
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    is strongly expressed in the aganglionic and ganglionic colon of patients with Hirschsprung disease (HSCR)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a valuable biomarker in psoriasis patients, both for diagnostic purposes and measurement of disease activity during the clinical course
  • Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    might provide a future drug target, because of its potential amplifier role in TNF- and IL17 pathways in psoriatic skin inflammation
    ANIMAL & CELL MODELS