SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,peroxisome
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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basic FUNCTION
| involved in mitochondrial morphology in distrituting mitochondrial tubules throughout the cytoplasm and in vesicle trafficking |
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involved in the formation and trafficking of coated vesicles |
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involved in mitochondrial fusion/fission and modulating apoptotic cell death at the mitochondrial level |
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playing a role in the mitochondrial fission in mitotic cells when phosphorylated on Ser-585 |
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key components in mitochondrial membrane fusion and division |
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its expression level constitutively regulate mitochondrial dynamics and cell survival in cortical neurons |
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function of the gene is needed for the maintenance of normal cellular function in a relatively tissue-specific manner |
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its posttranslational and dynamic modifications, contribute not only to the normal regulation of mitochondrial division, but also to neuropathologic processes |
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required for mitochondrial fission |
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stimulates BID-induced BAX oligomerization and cytochrome c release by promoting tethering and hemifusion of membranes |
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master regulator of mitochondrial fission ( |
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mitochondrial fission requires the dynamin-like protein DNM1L that is recruited to the mitochondrial surface, possibly through the membrane-anchored protein FIS1 or MFF |
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may act as a regulatory factor for efficient execution of both fusion and fission of mitochondria |
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DNM1L, and FIS1 are two key players of mitochondrial fission |
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PIM1 activity prevents DNM1L compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to simulated ischemia (sI) |
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may thus function as a node integrating signals from stress regulators, such as AMPK, to coordinate organelle shape and function |
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is required for TP53 translocation to the mitochondria under conditions of oxidative stress |
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GTPase that mediates mitochondrial and peroxisomal division in a process dependent on self-assembly and coupled to GTP hydrolysis |
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role not only in the formation of lipid tubes but also on the stabilization of tightly apposed membranes, which are intermediate states in the process of mitochondrial fission |
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DNM1L and parkin play synergistic roles in neuronal mitochondrial homeostasis and survival |
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astrocytic mitochondrial DNM1L is a key protein in mitochondrial dynamics and decreased DNM1L may interfere with neuron survival in Parkinson disease by disrupting Ca(2+)-coupled glutamate uptake |
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DNM1L and PARK2/Parkin work likely in a synergistic manner to maintain mitochondrial function and structural integrity in the heart and brain |
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in dividing mitochondria, membrane scission is accomplished by a dynamin-related GTPase, DNM1L, that oligomerizes at the site of fission and constricts in a GTP-dependent manner |
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DNM1l is a GTPase protein responsible for mitochondrial division, and SAMM50 is responsible for protein sorting and assembly |
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mitochondrial morphology is governed by the balance of mitochondrial fusion, mediated by mitofusins and optic atrophy 1 (OPA1), and fission, mediated by dynamin-related protein 1 (DNM1L) |
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role of DNM1L adaptor proteins MIEF2 and MIEF1 in mitochondrial fission |
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is a dynamin guanosine triphosphatase important for mitochondrial and peroxisomal division |
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mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DNM1L) and its mitochondrial receptors |
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cytosolic protein responsible for mitochondrial fission and essential in the initiation and development of several human diseases, including cancer |