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FLASH GENE
Symbol ZNF215 contributors: npt - updated : 05-05-2009
HGNC name zinc finger protein 215
HGNC id 13007
Location 11p15.4      Physical location : 6.947.653 - 6.979.277
Synonym name
  • BWSCR2 region,associated zinc finger protein 2
  • zinc finger protein with KRAB and SCAN domains 11
  • Synonym symbol(s) BAZ2, ZKSCAN11
    DNA
    TYPE functioning gene
    STRUCTURE 31.62 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure 5 exons coding
    MAPPING cloned Y linked N status provisional
    Map see BWSCR2
    regionally located in the BWSCR2 region
    RNA
    TRANSCRIPTS type messenger
    text five alternatively spliced transcripts, all disrupted in Beckwith-Wiedemann (Alders 2000)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3658 60 517 - Alders (2000)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING
    text imprinted in a tissue specific manner
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal SCAN box leucine-rich mediating self-association and oligomerization
  • a KRAB-A (Krüppel associated box), similar to a KRAB-B domain
  • five zinc finger motifs
  • a putative nuclear localization signal (NLS)
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans F56F11.3
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • SCAN subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS