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FLASH GENE
Symbol PREB contributors: mct/npt - updated : 05-12-2018
HGNC name prolactin regulatory element binding
HGNC id 9356
Location 2p23      Physical location : 27.353.624 - 27.357.542
Synonym name mammalian guanine nucleotide exchange factor mSec12
Synonym symbol(s) SEC12, MGC3467
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping
text
  • with ABHD1 contain a conserved 42 bp overlap in their 3'UTR, and share a conserved TTTATTAAA/TTTAATAAA sequence that serves as a polyadenylation signal for both genes
  • STRUCTURE 3.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif
    text structure
  • IP (PIT-J binding element)
  • a single polyadenylation signal, AATAAA, within the 3'UTR
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2211 45 417 - Edgar (2003)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text surface ectoderm, developing liver, Rathke's pouch, skeleton
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • highly conserved WD repeat domain
  • two PQ rich potential transactivation domains but no apparent DNA binding motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • prolactin regulatory element binding
  • transcriptional regulator role both in the pituitary and in other organs in which transcripts of its gene are expressed
  • promotes efficient guanine nucleotide exchange on the IQGAP1 GTPase in the endoplasmic reticulum
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • LTK-to-PREB signaling represents the first example of an ER-resident signaling module with the potential to regulate proteostasis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediating transcriptional activation of PRKA
  • PREB recruitment to ER exit sites is organized by its direct interaction with MIA2, a previously characterized collagen cargo receptor component, which functions together with MIA3 at ER exit sites
  • recruitment of PREB by MIA2 contributes to efficient activation of SAR1A in the vicinity of ER exit sites
  • MIA3 recruits membrane-bound macromolecular complexes consisting of MIA2 and PREB to the ER exit sites
  • cell & other
    REGULATION
    Phosphorylated by LTK, that interacts with and phosphorylates PREB
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS