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FLASH GENE

Symbol

TAX1BP3

contributors: shn/pgu - updated : 27-09-2012

HGNC name	Tax1 (human T-cell leukemia virus type I) binding protein 3
HGNC id	30684

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13      Physical location : 3.566.189 - 3.571.973
Synonym name	Tax interaction protein 1
	tax-interacting protein 1
	tax1-binding protein 3
	glutaminase-interacting protein 3
	glutaminase interacting protein
Synonym symbol(s)	TIP1, TIP-1, GIP

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - CTNS CTNS - TIP1 - P2RX5 - ITGAE - cen

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive intestine small intestine     highly Homo sapiens Nervous brain       highly Homo sapiens Respiratory lung       highly Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single PDZ domain
	S2P metal dependent membrane associated protease domain

HOMOLOGY

interspecies	ortholog to Tax1bp3, Mus musculus
	ortholog to tax1bp3, Danio rerio
	ortholog to TAX1BP3, Pan troglodytes

Homologene

FAMILY

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in Rho signaling to the serum response element
	functioning as a negative regulator of PDZ-based scaffolding
	may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand
	may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway
	TAX1BP3 may act as an important regulator for the endocytic pathway of KCNJ4

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	important roles in cellular signaling, protein scaffolding and modulation of tumor growth (

PATHWAY

metabolism

signaling

a component

Rho-rhotekin-TIP1

INTERACTION

DNA

RNA

small molecule

protein	Rho effector rhotekin (
	Glutaminase L (
	beta-catenin (
	Kir 2.3 (
	brain-specific angiogenesis inhibitor 2, BAI2
	FAS, HTLV-1 Tax, HPV16 E6,
	atypical PDZ-domain-containing protein, binding to KCNJ4 with a high affinity, causing the intracellular accumulation of KCNJ4 in cultured epithelial cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS