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FLASH GENE
Symbol TJP3 contributors: mct - updated : 04-02-2012
HGNC name tight junction protein 3 (zona occludens 3)
HGNC id 11829
Location 19p13.3      Physical location : 3.728.373 - 3.750.681
Synonym symbol(s) ZO-3, MGC119546
DNA
TYPE functioning gene
STRUCTURE 22.31 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 2859 - 952 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemovary  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal (MAGUK-like)
  • three Dlg (DHR/GLGZ/PDZ) motifs with a proline-rich region between PDZ2 and PDZ3
  • a SH3 domain
  • a C terminal acidic domain
  • HOMOLOGY
    interspecies homolog to yeast guanylate kinase
    homolog to Drosophila lethal dics large tumor suppressor protein Dlg
    homolog to murine Tjp3
    Homologene
    FAMILY MAGUK (membrane-associated guanylate kinase homolog) superfamily of cell junction proteins
    CATEGORY adhesion , chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • tight junction and zona occludens
  • shows an epithelial-specific Tight junction localization in a TJP1/TJP2-dependent fashion
  • basic FUNCTION
  • F actin filament binding scaffold protein, mediating interactions with claudins in tight junction plaques
  • important role in regulating epithelial cell proliferation through stabilization of cyclin D1 during mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component structural component of tight junction and adherens junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to the C terminus of claudins, occludin and ZO-1
  • can associate with INADL (INADL/TJP3 interaction is likely important for recruiting INADL and its associated proteins to tight junctions)
  • bind to the C-terminus of OCLN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS