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FLASH GENE
Symbol SLCO3A1 contributors: mct - updated : 02-10-2019
HGNC name solute carrier organic anion transporter family, member 3A1
HGNC id 10952
Location 15q26.1      Physical location : 92.396.937 - 92.715.665
Synonym name
  • solute carrier family 21 (organic anion transporter), member 11
  • PGE1 transporter
  • organic anion transporter polypeptide-related protein 3
  • organic anion-transporting polypeptide D
  • sodium-independent organic anion transporter D
  • Synonym symbol(s) OATP-D, SLC21A11, OATP3A1, FLJ40478
    DNA
    TYPE functioning gene
    STRUCTURE 318.73 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2853 - 692 predominantly expressed in testis and brain 2007 16971491
  • lacking 18 amino acids (aa) at the C-terminal end
  • 10 - 5102 - 710 exhibits a wide tissue distribution, with expression in testis, various brain regions, heart, lung, spleen, peripheral blood leukocytes, and thyroid gland 2007 16971491
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systembreast    Homo sapiens
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains
  • N-glycosylation sites
  • HOMOLOGY
    intraspecies homolog to rat Oatpd (97.6 p100)
    Homologene
    FAMILY SLC21A superfamily of solute carriers
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • SLCO5A1 and SLCO3A1 localized to the plasma membrane of epithelial cells of the lactiferous ducts in normal breast tissue
  • basic FUNCTION
  • transport of 3(H) estrone-3-sulfate
  • plays an important role in translocating prostaglandins in specialized tissues and cells
  • SLCo3A1 variants might be involved in the regulation of extracellular vasopressin concentration in brain and thus might influence the neuromodulation of neurotransmission by cerebral neuropeptides such as vasopressin
  • mediates inflammatory processes in intestinal epithelial cells through NFKB1 transcription activation, resulting in a higher incidence of bowel perforation in Crohn Disease patients
  • potential mechanism for SLCO3A1 downregulation that involves DNA methylation during colorectal carcinogenesis
  • SLCO3A1 functions as a bile acid efflux transporter that is up-regulated as an adaptive response to cholestasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    SLCO1B3, SLCO2A1, SLC33A1 and SLCO4A1 are up-regulated in pancreatic adenocarcinoma (
    tumoral     --low  
    in colorectal cancer patients
    Susceptibility
  • to alcool and nicotine dependence
  • to intestinal perforation in Crohn disease (CD) patients
  • Variant & Polymorphism other
  • rs207959 (T) allele is a risk allele that alters SLCO3A1 mRNA expression and is associated with intestinal perforation in CD patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS