basic FUNCTION
| playing a key role in the development of lip and palate, skin, external genitalia |
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functioning as a co-operative transcriptional activator |
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plays a key role in the formation and maintenance of the oral periderm, spatio-temporal regulation of which is essential for ensuring appropriate palatal adhesion |
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IRF6 and the Notch ligand JAG2 function in convergent molecular pathways during oral epithelial differentiation |
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regulates craniofacial development and epidermal proliferation |
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function for IRF6 in suppression of tumorigenesis in stratified epithelia |
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potential tumor suppressor gene in squamous cell carcinomas, acting on a gene network that contributes to the regulation of cancer cell invasiveness and proliferation |
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essential role in epidermal development, is induced in differentiation through a NOTCH1-dependent mechanism and is a primary NOTCH1 target in keratinocytes |
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IRF6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue |
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IRF6 and GRHL3 are essential for the presence of a functional oral periderm and that failure of this process contributes to VWS |
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IRF6 is a mediator of TGFB3, which regulates EMT and fusion process during the embryonic palate development |
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RIPK4 and IRF6 function as a cell-intrinsic signaling axis to regulate keratinocyte differentiation |
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IRF6 regulates TFAP2A protein level in epidermal development 3) |
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IRF6 and TFAP2A are part of a genetic regulatory network that is critical in epithelial development, with implications for both orofacial and cutaneous tissues 3) |
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homeostasis of IRF6 is required for development of the neural tube and associated structures |
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during head and neck development, IRF6 is involved in the structure formation of the oral and maxillofacial regions, and TGFA is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis |
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IRF6 is a transcription factor that is required for craniofacial development and epidermal morphogenesis |
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role for IRF6 in the delivery of adhesion proteins to the cell membrane |
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IRF6 controls the appearance of single cells and colonies, with the latter being less cohesive in its absence |