basic FUNCTION
| coordinated assembly of focal adhesions and stress fibers |
|
linking growth factor receptors to the activation of actin polymerization |
|
role in signaling the neutrophil respiratory burst stimulated by G protein-coupled receptor agonists |
|
playing a critical role in muscle differentiation |
|
mediating the distinct actin cytoskeleton |
|
changes required for both cellular motility and cell-cell adhesion |
|
potentially promoting neural progenitor cells proliferation through PI3K in cortical development |
|
functions upstream of the ELMO1/DOCK1 complex, and is also important for spine formation |
|
functions to promote spine morphogenesis |
|
RAC1 is required for ICAM1 clustering, whereas RHOG controls membrane protrusion formation |
|
critical role for RHOG in glioblastoma tumor cell invasion and survival |
|
orchestrates processes integral to platelet function, including actin cytoskeletal rearrangement and membrane trafficking |
|
functions of RhoG in platelets are particularly relevant to thrombotic disorders |
|
RHOG is essential for normal granule secretion downstream of the collagen receptor GP6 |
|
exogenous expression of ELMO2 or RHOG stabilizes microtubules, but only if ILK is also present |