Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | UPB1 | contributors: - updated : 18-12-2004 |
HGNC name | ureidopropionase, beta |
HGNC id | 16297 |
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Corresponding disease |
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Location | 22q11.2 Physical location : 24.891.250 - 24.922.552 | ||
Synonym name | |||
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Synonym symbol(s) | BUP1 | ||
EC.number | 3.5.1.6 |
DNA |
TYPE | functioning gene |
STRUCTURE | 20.00 kb 11 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
| one CN hydrolase domain |
mono polymer | homomer , hexamer |
HOMOLOGY |
interspecies | ortholog to rattus Ubp1 |
Homologene |
FAMILY | CN hydrolase family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm |
basic FUNCTION | catalyzing the last step in the pyrimidine degradation pathway |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | purine/pyrimidine |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
zinc Zn2+ |
protein |
cell & other |
REGULATION |
inhibited by | propionate |
ASSOCIATED DISORDERS |
corresponding disease(s) | UPB1 |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |