SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,granule
|
text
| membrane bound, colocalizing with melanosomes |
basic FUNCTION
| being a small GTPase, key effector of cytotoxic granule exocytosis, vesicle transport and organelles dynamics, targeting transport and fusion of vesicles with their appropriate membrane acceptors |
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RAB27A, MYRIP and MYO7A bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles |
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involved in the transport of melanosomes to the cell periphery |
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involved in other fundamental physiological functions, such as the transport of lytic granules and insulin secretion |
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required for both granule maturation and granule docking and priming at the immunologic synapse |
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involved in terminal phases of cytotoxic granule/melanosome exocytosis |
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may facilitate degranulation at an early step |
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may regulate with MYRIP the amount and multimeric state of VWF released from endothelial cells |
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functions in the multivesicular endosome docking at the plasma membrane and secretion pathway |
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RAB27A and RAB27B control different steps of the exosome secretion pathway |
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RAB27A, RAB27B play independent roles in neutrophil exocytosis |
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distinct role of RAB27A in granule movement at the plasma membrane and in the cytosol of NK cells |
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is involved in the exocytosis of secretory granules in melanocytes and cytotoxic T-cells |
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plays a direct regulatory role in the nascent process of phagocytosis by prolongation of the stage of actin coating via suppression of CORO1A |
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RAB27A, RAB38 and RAB32 function in melanosome maturation or trafficking in melanocyte |
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regulates motility of lysosome-related organelles and secretory granules |
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RAB27A/MYRIP/MYO5A complex is involved in linking Weibel-Palade bodies (WPB) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of VWF |
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RAB3A and RAB27A regulate late steps during dense-core vesicle exocytosis in neuroendocrine cells |
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intrinsically essential role of RAB27A in human ethnic skin color determination |
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RAB27A and RAB27B regulate exocytosis of multivesicular endosomes |
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supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression |
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mediates insulin exocytosis not only through SYTL4, but also through other effectors expressed in pancreatic beta cells |
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GTPase activity of RAB27A is required for its melanosome localization but is not required for melanosome transport |
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regulates lysosomal exocytosis and myelin protein trafficking in Schwann cells |
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RAB27A lipid modification, and activation/inactivation status correlate with its stimulatory or inhibitory roles in exocytosis |
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RAB27A can play divergent roles in regulating pro-metastatic propensity of pancreatic cancer cells |
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contributes to CTSS secretion in lacrimal gland acinar cells |
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RAB27A-mediated paracrine communication regulates the development of synaptic connectivity, ultimately tuning responses to sensory stimulation, possibly via controlling the release of small extracellular vesicles (sEVs) |
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RAB27A is identified as an onco-protein in mediating Colorectal cancer development |