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Symbol PPIL2 contributors: npt/ - updated : 15-11-2005
HGNC name peptidylprolyl isomerase (cyclophilin)-like 2
HGNC id 9261
Location 22q11.22      Physical location : 22.020.272 - 22.052.201
Synonym name
  • cyclophilin-like protein CyP-60
  • cellular target of cyclosporin
  • rotamase
  • Synonym symbol(s) Cyp-60, CYC4, CYP60, FLJ39930, MGC33174, MGC787, PPIase
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 31.93 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S420 - GGT2 - D22S927 - SERPIND1 - D22S446 - PPIL2 - D22S539 - ADORA2A - D22S429 - qter
    Authors Gene Map (99)
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4128 58.7 520 - -
    - - 2878 58.7 520 - -
    - - 2736 59.4 527 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Endocrinepancreas    
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a sequence similar to known cyclophilin flanked by unique N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclophilin-type PPIase family
  • PPIL2 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text specific
    basic FUNCTION
  • maybe playing a specific role in the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS