SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,nucleus,nucleoplasm
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| localize to the mammalian P bodies |
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its subcellular localization is regulated by its own nuclear localization signal and nuclear export signal |
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TNRC6A shuttles between the cytoplasm and nucleus |
basic FUNCTION
| may be having a role in regulating neurodevelopment or neuroplasticity |
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may be involved in structure/maintenance and/or stability of GW body (GWB) structures |
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might contribute to diversity in the formation and function of GW and/or P bodies |
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is likely an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene silencing |
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could mediate repression without activating the rapid degradation of the associated mRNA |
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is capable of nucleating the de novo formation of GW/P bodies and is essential for their maintenance in mammalian cells |
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different TNRC6 proteins (TNRC6A, TNRC6B, TNRC6C) have likely distinct functions in different types of RNA granules |
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possibility that TNRC6A plays an important role in navigating AGO protein into the nucleus to lead miRNA-mediated gene silencing |
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is an essential protein for microRNA-mediated gene silencing |
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regulates splicing in the nucleus |
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TNRC6A/TNRC6B/TNRC6C are central organizing factors critical to RNA-mediated transcriptional activation |
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central scaffold that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes |
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TNRC6A, TNRC6B, TNRC6C are required for transcriptional activation and for the activity of miRNAs but are dispensable for the regulation of splicing, transcriptional silencing, and the action of siRNAs |