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FLASH GENE
Symbol SEC24C contributors: mct/npt - updated : 19-12-2011
HGNC name SEC24 related gene family, member C (S. cerevisiae)
HGNC id 10705
Location 10q22.2      Physical location : 75.504.131 - 75.531.917
Synonym name
  • protein transport protein SEC24C
  • similar to a putative C.elegans gene encoded in cosmid F12F6
  • Synonym symbol(s) KIAA0079, SEC24p
    DNA
    TYPE functioning gene
    STRUCTURE 27.80 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D10S188 - SEC24C - D10S535 - D10S195 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 4563 118.3 1094 - 2008 18329616
    23 - 4476 118.3 1094 - 2008 18329616
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Sec24p
    Homologene
    FAMILY
  • SEC23/SEC24 family
  • SEC24 subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text associated with COPII structures on membranes of the ER-Golgi boundary
    basic FUNCTION
  • vesicle biogenesis from endoplasmic reticulum
  • role in selective export of membrane proteins from the endoplasmic reticulum
  • required for docking the prechylomicron transport vesicle with the Golgi
  • variations in the SEC24C gene may also affect SLC6A4 cell surface levels and thus be linked to mood disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC13, SEH1L
  • interacting with SLC6A4 (SLC6A4 can only exit the ER by recruiting SEC24C)
  • a triple arg motif mediates ADRA2B interaction with SEC24C/D and export from the endoplasmic reticulum (ER)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS