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FLASH GENE

Symbol

DGKB

contributors: mct/npt - updated : 30-05-2018

HGNC name	diacylglycerol kinase, beta 90kDa
HGNC id	2850

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p22.2      Physical location : 14.184.674 - 14.881.075
Synonym name	DAG kinase beta
	diglyceride kinase beta
Synonym symbol(s)	KIAA0718, DAGK2, DGK, DGK-BETA
EC.number	2.7.1.107

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	693.64 kb     24 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	several isoforms differing by alternative splicing and the usage of different polyadenylation signals

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DGKB variant 1 - - 3926 90 804 - Caricasole (2002) variant 2 - - 3172 87 772 - Caricasole (2002)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly   nerve       highly Reproductive female system uterus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N terminal EF hand calcium-binding domains
	two phorbol esters/diacylglycerol binding domain (C1 domain)
	a DAG catalytic domain
	a DAG accessory domain
	cysteine-rich zinc finger like (? LIM domain) and putative ATP-binding sites

HOMOLOGY

interspecies

homolog to rattus diacylglycerol

Homologene

FAMILY

eukaryotic diacetylglycerol kinase family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	one variant to cytoplasm, the other to plasma membrane

basic FUNCTION	key enzymes in lipid metabolism that function to reintroduce diacylglycerol formed from the hydrolysis of phospholipids into the biosynthetic pathway
	invoved in phosphorylation of long chain diacetylglycerols

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	Ca2+
	ATP

protein

cell & other

REGULATION

activated by

stimulated phosphatidylserine

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in Wilms tumor

Susceptibility

to decreased glucose-stimulated insulin response

Variant & Polymorphism other	variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS