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FLASH GENE
Symbol ARHGAP32 contributors: mct/ npt - updated : 29/10/2008
HGNC name Rho GTPase activating protein 32
HGNC id 17399
Location 11q24.3      Physical location : 128.834.955 - 129.062.093
Genatlas name Rho GTPase-activating protein
Synonym name
  • GAB-associated CDC42
  • rac GTPase activating protein
  • brain-specific Rho GTP-ase-activating protein
  • RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
  • Synonym symbol(s) GRIT, GC-GAP, MGC1892, KIAA0712, p200RhoGAP, PX-RICS, RICS
    DNA
    TYPE functioning gene
    STRUCTURE 227.14 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D11S1351 - FLI1 - RICS - APLP2 - D11S4131 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 9443 191 1738 - 2003 12454018
    18 - 10111 - 2087 - 2003 12454018
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     pharynx   highly
    Hearing/Equilibriumear   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved RhoGAP domain at the N terminus
  • multiple proline-rich motifs in the C-terminal region
  • TRKA-binding region with two potential SH3-binding motifs
  • HOMOLOGY
    interspecies ortholog to murine Grit
    Homologene
    FAMILY
  • GTPase-activating protein for the Rho family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulating neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules
  • may regulate dendritic spine morphology and strength by modulating Rho GTPases
  • involved in the synaptic adhesion- and N-methyl-D-aspartate-mediated organization of cytoskeletal networks and signal transduction
  • involved in the regulation of neurite outgrowth by exerting its RhoGAP activity and its cellular activity may be regulated through interaction with Src-like tyrosine kinases
  • beta-catenin-interacting GTPase-activating protein (GAP) for CDC42, mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex
  • required for ER-to-Golgi transport of the fibroblast growth factor-receptor 4 (FGFR4) associated with N-cadherin
  • its activity increased in the presence of PTPRS leading to attenuated RAC activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TrkA receptor and N-Shc and CrkL/Crk adapter molecules
  • novel substrate of PTPRS and PTPRS displayed its phosphatase specificity toward ARHGAP32
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS