basic FUNCTION
| regulating the cardiac development and in the developing of Schwann cells of the peripheral nervous system |
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playing a key role in the differentiation of male gonads |
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combinatorial expression of the paracrine factor DHH and nuclear transcription factor SF1 is required for Leydig cell development |
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is essential for testis development and Schwann cell function |
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DHH promotes peripheral nerve survival in the ischemic muscle and, by doing so, maintains the pool of nerve-derived proangiogenic factors |
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controls the formation of the nerve perineurium during development and is a key component of Schwann cells that ensures peripheral nerve survival |
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pivotal role for DHH in maintaining myelination |
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critical role of DHH in maintaining blood nerve barrier integrity, demonstrating time that endothelial dysfunction is sufficient to induce neuropathy |