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FLASH GENE
Symbol OSTF1 contributors: mlc/np - updated : 29-05-2013
HGNC name osteoclast stimulating factor 1
HGNC id 8510
Location 19q21.13      Physical location : 77.703.397 - 77.762.113
Synonym name
  • SH3 domain protein 3
  • human osteoclast stimulating factor mRNA, complete cds
  • Synonym symbol(s) OSF, SH3P2, FLJ20559, bA235O14.1
    DNA
    TYPE functioning gene
    STRUCTURE 58.72 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1313 23 214 - 2004 1513504
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Nervousnerve   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a c-Src homology 3 domain (SH3)
  • ankyrin repeats domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • indirectly enhancing osteoclast formation and osteoclastic bone resorption through the cellular signal transduction cascade, possibly through its interactions with c-Src or other Src-related proteins
  • SH3-domain containing protein, a novel Cbl-interacting molecule that is a substrate of tyrosine kinase Src
  • is an essential molecule that functions downstream of the ERK pathway to modulate cell motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    PATHWAY
    metabolism
    signaling
    a component
  • component of adhesion sites, involved in Cbl and Src-mediated pathways
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • c-Src or other Src-related proteins
  • associated with Cbl and fibrilar actin
  • interacting with SMN through the OSF-Src homology 3 domain (interaction may provide more insights into novel cellular signaling mechanisms that may play an important role in congenital bone fractures associated with type I spinal muscular atrophy disease)
  • interaction between KHDRBS1 and OSTF1 complements the known KHDRBS1-SRC and OSTF1-SRC interactions
  • cell & other
    REGULATION
    Phosphorylated by on Ser(202) by RPS6KA1 in an ERK pathway-dependent manner, and such phosphorylation inhibited the ability of OSTF1 to suppress cell motility
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS