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FLASH GENE
Symbol ENSA contributors: mct - updated : 27-05-2011
HGNC name endosulfine alpha
HGNC id 3360
Location 1q21.2      Physical location : 150.594.603 - 150.602.098
Synonym symbol(s) ARPP-19e, MGC4319, MGC78563, MGC8394
DNA
TYPE functioning gene
STRUCTURE 7.50 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1300 - 137 - 2004 15030171
4 - 1252 - 121 - 2004 15030171
- - 2931 - 133 - 2004 15030171
- - 2883 - 117 - 2004 15030171
5 - 1164 - 133 - 2004 15030171
4 - 1116 - 117 - 2004 15030171
- - 2747 - 113 - 2004 15030171
- - 771 - 105 - 2004 15030171
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   lowly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Ensa
Homologene
FAMILY
CATEGORY regulatory , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • endogenous regulator of the beta-cell K (ATP) channel
  • inhibiting sulfonylurea binding to beta cell membranes
  • stimulating insulin secretion and controling insulin release
  • coupling cell metabolism to electrical activity
  • conserved protein potentially required for oocyte meiotic maturation
  • in the absence of MASTL activity, ARPP19 and ENSA are dephosphorylated and lose their capacity to bind and inhibit PPP2R2B
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    text
  • small molecule transport
  • nutriment absorption
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endogenous ligand of sulfonylurea receptor(ABCC8)
  • ENSA and ARPP19 are substrates of MASTL (are phosphorylated by MASTL and act downstream of this kinase to promote mitotic entry, possibly by directly inhibiting PPP2R2B)
  • cell & other
    REGULATION
    Other phosphorylated by PKA
    phosphorylated in mitosis by the protein kinase Greatwall (MASTL)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility minor contributor to susceptibility to non insulin dependent diabetes mellitus
    Variant & Polymorphism SNP SNP 17 associated with reduction of insulin secretion
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS