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FLASH GENE
Symbol TIMM10 contributors: npt/mct - updated : 25-08-2010
HGNC name translocase of inner mitochondrial membrane 10 homolog (yeast)
HGNC id 11814
Location 11q12.1      Physical location : 57.295.935 - 57.298.232
Synonym name mitochondrial import inner membrane translocase subunit Tim10
Synonym symbol(s) TIM10, TIM10A
DNA
TYPE functioning gene
STRUCTURE 2.30 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D11S1357 - TIMM10 - D11S1765 - qter
Authors Jin(99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 684 10.2 90 - Webb (20006)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus   highly
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a largely alpha-helical structure
  • one on the N terminal region
  • one central comprising two cysteine residues
  • a central loop flanked by disulfide bonds that separate two extended N- and C-terminal tentacle-like helices (Baker 2009)
  • a third one and separated from each other by random coil and suggesting a hairpin of helices held together by the cysteine coodination of the Zn2 + ion
  • a region of nine AAs, functioning as a signal for the engagement of substrate proteins, and facilitating the transfer of proteins across the outer membrane to the intermembrane space (Milenkovic 2009)
  • mono polymer heteromer , oligo
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae translocase of inner mitochondrial membrane 10 (Tim10p)
    Homologene
    FAMILY
  • small Tim family
  • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text mitochondrial TIMM9-TIMM10 translocase complex, located in the mitochondrial intermembrane space (Ivanova 2008)
    basic FUNCTION
  • essential for escorting a class of multimembrane-spanning proteins
  • with TIMM9, plays an essential chaperone-like role during the import of mitochondrial membrane proteins (Ivanova 2008)
  • TIMM9-TIMM10 complex plays an essential role in mitochondrial protein import by chaperoning select hydrophobic precursor proteins across the intermembrane space (Baker 2009)
  • acting in substrate recognition (Baker 2009)
  • mediating the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane
  • required to mediate translocation of ADP/ATP carrier across the outer membrane (Hasson 2010)
  • role for the TIMM9-TIMM10 complex in the import of Tafazzin (TAZ) and TIMM22, but not TIMM23 (Hasson 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS