SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
| intracellular,nucleus
|
text
| localized in endosomes but also capable of nucleocytoplasmic shuttling |
|
resides on a tubulo-vesicular compartment that is capable of sorting cargo for recycling or degradation and that displays long lifetimes, all features typical of early endosomes |
basic FUNCTION
| recruiting kinases AKT2 and PIK3 to the cell membrane |
|
protein serine/threonine kinase, mediating the DCC apoptotic pathway |
|
selectively regulates apoptosis during development by controlling AKT1 signaling |
|
may be involved in cell division |
|
acting as a critical regulator of the crosstalk between adiponectin signaling and insulin signaling pathways |
|
may suppress androgen receptor transactivation via potentiating AKT1 activity |
|
mediates AKT1 substrate specificity and cell survival in vertebrate development |
|
its overexpression has a proapoptotic effect |
|
activator of beta-catenin/TCF-mediated transcription |
|
may act as a scaffold that modulated Rab5-associated signaling endosomal membrane by its ability to undergo domain-mediated oligomerizatio, membrane targeting and phosphoinositide binding |
|
recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment |
|
APPL1 and APPL2 appear to play important roles in cargo trafficking and signal transduction |
|
required for EGFR signaling by regulation of EGFR stabilities through inhibition of RAB5A |
|
role in regulating cell migration and adhesion turnover through a mechanism that depends on SRC and AKT1 |
|
obligatory role of APPL1 in insulin secretion |
|
role of APPL1 as a key regulator that couples insulin signaling to insulin secretion in beta cells |
|
positive regulator of transcriptional activity of NFKB under basal but not TNF-stimulated conditions |
|
APPL1 synergized with TRAF2 to induce NFKB activation, and both proteins were necessary for this process and function upstream of the IKK complex |
|
plays a critical role in regulating adiponectin and insulin signaling |
|
important mediator of insulin and adiponectin signaling |
|
APPL1 sensitizes insulin signaling by acting at a site downstream of the INSR |
|
critical role of APPL1 in glucose homeostasis |
|
APPL1 endosomes represent a distinct population of RAB5-positive sorting endosomes, thus providing important insights into the compartmental organization of the early endocytic pathway |
|
plays a critical role in regulating adiponectin and insulin signaling pathways |
|
negatively regulates inflammation and apoptosis in pancreatic beta cells |