basic FUNCTION
| regulating the formation of clathrin-coated vesicles |
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functioning in the induction of T cell antigen receptor (TCR) |
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SH3/SH2 adaptor protein |
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ITSN1 and ITSN2 are conserved proteins involved in clathrin-mediated endocytosis |
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guanine nucleotide exchange factor for CDC42, regulating different steps of caveola endocytosis in Endothelial cells by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane |
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multimodule scaffolding protein functioning in membrane-associated molecular trafficking and signal transduction pathways |
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ITSN1 and ITSN2, are crucial for the initiation stage of clathrin-mediated endocytosis |
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during evolution of vertebrates ITSN2 acquired a novel protein-interaction interface that allows its specific recognition by the SH2 domains of signaling proteins |
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ITSN1, ITSN2 are scaffold proteins involved in the molecular mechanisms of invadopodia formation |