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FLASH GENE
Symbol GSPT2 contributors: mct - updated : 24-11-2015
HGNC name G1 to S phase transition 2
HGNC id 4622
Location Xp11.22      Physical location : 51.486.480 - 51.489.324
Synonym name
  • peptide chain release factor 3b
  • eukaryotic peptide chain release factor subunit 3b
  • Synonym symbol(s) ERF3B, GST2, FLJ10441, eRF3b
    DNA
    TYPE functioning gene
    STRUCTURE 2.85 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - DXS1058 - DXS7045 - DXS1039 - DXS7048 - GSPT2 - DXS1199 - cen
    Authors Hansen (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2861 68.7 628 - 1998 9712840
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an elongation factor Tu domain
  • HOMOLOGY
    interspecies ortholog to murine Gspt2
    homolog to Drosophila Elf
    homolog to C.elegans H19N07.1
    intraspecies homolog to GSPT1
    Homologene
    FAMILY
  • GTP-binding elongation factor family
  • ERF3 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • translation elongation factor
  • GSPT1 is the major factor acting in translation termination in mammals and GSPT2 can substitute for GSPT1 in this function
  • GSPT2 originated through retrotransposition of processed GSPT1 transcript into the genome
  • CELLULAR PROCESS cell cycle, checkpoint
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • GTP
  • protein
  • ETF1
  • GSPT2 overexpression alleviated the effect of GSPT1 silencing on readthrough and on ETF1 cellular levels
  • interaction between BIRC5 and GSPT1, GSPT2
  • biomarker for hepatocellular carcinoma, influencing cell cycle and phosphoralation status of EIF4EBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS